In 1978, when Nikki and Casey lived with their mother, both were said to be promiscuous. Casey was very protective of Nikki, but Nikki rarely took her older sister's advice, as she considered it hypocritical. During the years that Casey was living in Genoa City, it was revealed that their father had sexually assaulted Casey as a young girl, thereby giving an explanation for Casey's promiscuity and for her infamous distrust of men. The misguided Nikki, a talented pianist, fell into working as a stripper.
While Casey, a brilliant and caring young woman, worked diligently to become a doctor. Her closest associate was Dr. Snapper Foster who was married to Chris Brooks. Snapper had deep admiration for Casey, and when he and his wife split up for a time, he fell for her. Unfortunately for Casey, by the time she was ready to take the plunge and confess that she felt the same way, Chris took him back. An unselfish Casey put her own desire aside and encouraged Snapper to give his marriage another chance.
In 1998, Dr. Casey Reed was by her sister Nikki's side when she finally married Victor Newman and was saved from a life on the wrong side of the tracks. Casey also returned at different times in Nikki's life to offer support - such as the time when Victor had left Nikki for Ashley Abbott and Nikki then found out she could be dying!
- Nick Reed (father; deceased)
- Nikki Newman (sister)